虽然3DS主打立体特性，但是由于3D给用户带来的负面影响同样饱受诟病。英国皇家眼科医学院副院长Larry Benjamin就指出，3DS对用户健康和视觉都存在负面影响。
Larry Benjamin在试玩3DS后表示：“如果你的视角偏离5度，3D立体特效就会消失，而且容易引起眼睛疲劳。为了看到3D效果你就得不断进行视角调整，这让我感到反胃（想呕吐）。我认为有必要提醒用户它可能会使你眼睛疲劳、产生复视觉或者难以集中注意力。”
他总结道，为了呈现更利于健康的立体特效，任天堂之前应该进对此进行多次测试。
在Larry Benjamin之前也有用户产生过类似抱怨、健康专家也发出过提醒，任天堂也承认用户可能会产生不适体验，但不会影响健康。
原文：
Prominent ophthalmologist comments on 3DS usage, felt “queasy”
The vice president of England’s Royal College of Ophthalmologists, Larry Benjamin, has weighed in on the potential negative effects of the 3DS on health and vision.
“If you’re just five degrees off, it doesn’t quite work, which is tiring for the eyes,” Benjamin told The Independent after trying the new handheld.
“You continually have to readjust to 3D vision and that’s making me feel a bit queasy. I think it’s fair to warn people they may experience eye strain, double vision or difficulty focusing.
“I think it’d be sensible to do longer-term trials on it,” he concluded.
Benjamin’s comments join a number of similar warnings from health professionals and complaints from users.
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